Genmab — November 2018
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I had a gander at the durability of the drug - seems if it is refrigerated dara has a shelf life of 24 months
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you can keep dara in your fridge at home and shoot it just like insulin
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maybe its just a question of the trial results coming in? there could be a difference between relatively healthy first line / maintenance patients and subsequent lines
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Men eet er den kæmpe fordel der ligger i tidsbesparelsen og de færre bivirkninger. Noget andet er hvis sc også er mere effektiv. Hvis de 52% ORR i Pavo holder vand - og hvis pts kan sammenlignes med Sirius - Så er det næsten en fordobling af egeneffektiviteten, og historiebøgerne vil skulle skrives om. Alle hidtil kendte data fra Castor, Pollux, Maia mv vil være forældede. Og vi vil formentlig se helt andre effektdata i kombinationerne.
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i første omgang vil jeg stille mig tilfreds med, at sc klarer safety - det er hurdlen for at komme til den egentlige fordel. Effektforbedringer vil være icing on the cake for mig
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...men noget kan tyde på, at "molekyleniveauet" daler ved IV administration og SC rent faktisk giver en effektfordel. Det er sgu win-win
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De vil nok forlange højere pris for SC, pga HALO skal have en bid auf kagen...
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auf=af
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Det har jeg svært ved at bedømme lige nu - der vil være en kæmpe volumenmæssig fordel i maintenance. Måske det kan modvirke en prisforhøjelse?
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Cost+ prissætningen fungerer ikke altid
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AMGN420 did start august 2015 https://clinicaltrials.gov/ct2/show/NCT02514239
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https://ash.confex.com/ash/2018/webprogram/Paper109769.html and it looks like an car accident when you read it.
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det er i hvert fald ikke en kur! hold da kæft
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