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Genmab — November 2018

Planlagt Fastgjort Låst Flyttet Genmab
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  • SolsenS Offline
    SolsenS Offline
    Solsen
    wrote on sidst redigeret af
    #268

    NBI i +3,5% - har markedet altid ret. Bindegale udsving.

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    • T Offline
      T Offline
      transalp
      wrote on sidst redigeret af
      #269

      Enig.. jeg var da ved at gå i chok, da gen ab og dara blev nævnt i DR pressen da MAIA resultater kom.. ret vildt..

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      • B Offline
        B Offline
        bibob
        wrote on sidst redigeret af
        #270

        GMXAY + 5,71.

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        • BulderB Offline
          BulderB Offline
          Bulder
          wrote on sidst redigeret af
          #271

          E L: From Lyra: After induction, pts could undergo autologous stem cell transplantation (ASCT) - so they were also candidates. I don't think more frail than Griffin pts.

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          • BulderB Offline
            BulderB Offline
            Bulder
            wrote on sidst redigeret af
            #272

            The same goes for the small Irish cybord study: newly diagnosed MM (NDMM) pts eligible for ASCT

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            • BulderB Offline
              BulderB Offline
              Bulder
              wrote on sidst redigeret af
              #273

              The excitement in the conclusion is modest: Dara-CyBorD was active and well tolerated

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              • BulderB Offline
                BulderB Offline
                Bulder
                wrote on sidst redigeret af
                #274

                I'll ask Winkel if the results are worth a large phase 3 study.

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                • E Offline
                  E Offline
                  E_L
                  wrote on sidst redigeret af
                  #275

                  yes, true, i was more thinking compared to the studies we already now, the Polux/ Alcyone/Maia etc, sry

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                  • E Offline
                    E Offline
                    E_L
                    wrote on sidst redigeret af
                    #276

                    But would be a good question...

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                    • E Offline
                      E Offline
                      E_L
                      wrote on sidst redigeret af
                      #277

                      it may have a different toxicity profile and therefore still be good for some patients even if the results would be a bit disapointing?

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                      • E Offline
                        E Offline
                        E_L
                        wrote on sidst redigeret af
                        #278

                        the more options the better i guess…

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                        • BulderB Offline
                          BulderB Offline
                          Bulder
                          wrote on sidst redigeret af
                          #279

                          I see. No doubt that Griffin pts are better than Maia pts. But equal to Cass pts.

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                          • BulderB Offline
                            BulderB Offline
                            Bulder
                            wrote on sidst redigeret af
                            #280

                            I remember Michael E O'Dwyer in a video saying that DRd or DRVd suffers from a considerable financial toxicity. The Irish can't afford it.

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                            • SolsenS Offline
                              SolsenS Offline
                              Solsen
                              wrote on sidst redigeret af
                              #281

                              In 2023 R goes off patent...

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                              • BulderB Offline
                                BulderB Offline
                                Bulder
                                wrote on sidst redigeret af
                                #282

                                Regarding Maia and Griffin. In Griffin we had 100% vgpr or better. I don't think we'll se that in Maia. But hopefully 100% PR or better.

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                                • E Offline
                                  E Offline
                                  E_L
                                  wrote on sidst redigeret af
                                  #283

                                  it looks like Cyclophosphamide is a lot cheaper? Not sure if the dosing is 100% correct, but differnce looks large
                                  http://ascopubs.org/doi/pdfdirect/10.1200/EDBK_200867

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                                  • G Offline
                                    G Offline
                                    gentogen
                                    wrote on sidst redigeret af
                                    #284

                                    Det lille CybordD har fulgt patienterne længere (post asct): "Responses deepened post ASCT with 100% achieving ≥ VGPR and 62% achieving ≥ CR. Based on EBMT criteria the CR/nCR rate post ASCT was 92%. Post ASCT PET-CT scans were consistent with complete metabolic response in all 13 patients". Ved ikke, jvad der ellers ses, men lyder vel OK.

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                                    • SolsenS Offline
                                      SolsenS Offline
                                      Solsen
                                      wrote on sidst redigeret af
                                      #285

                                      HR er tilsyneladende med seneste opdatering 0,43 i Alcyone - på ASCO stod der 0,5.

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                                      • JørgenVarnæsJ Offline
                                        JørgenVarnæsJ Offline
                                        JørgenVarnæs
                                        wrote on sidst redigeret af
                                        #286

                                        hold da op - det er da en udvikling, der er til at mærke. Så er det bare om at de andre fase 3 data kan udvikle sig på sammen måde/retning

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                                        • BulderB Offline
                                          BulderB Offline
                                          Bulder
                                          wrote on sidst redigeret af
                                          #287

                                          Og endnu mere bemærkelsesværdigt idet pfs for VMP er øget med 1 måned http://www.multiplemyelomahub.com/medical-information/ash-2017-phase-iii-alcyone-clinical-trial-daratumumab-plus-bortezomib-melphalan-and-prednisone-d-vmp-in-ndmm-patients-ineligible-for-transplant

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