Genmab — Oktober 2018

[Nickstar]

JV! Tak for input. Vi ser virkeligheden på samme måde! I hvert fald ift gen

[E_L]

Causes for Relapse in Multiple Myeloma With CAR T cells https://www.targetedonc.com/videos/causes-for-relapse-in-multiple-myeloma-with-car-t-cells

[E_L]

https://www.patientpower.info/video/a-look-ahead-expert-perspective-on-car-t-cell-therapy-vs-transplant-in-myeloma/
Dr. Krishnan:
"Exactly. We do know too is you first have to reduce the amount of myeloma in the body for CAR-T to work well and also to reduce the toxicity of CAR-T. So you can't just take someone with newly diagnosed myeloma and give them CAR-T cells"

[Bulder]

..."no longer functionally persistent." Which probably means another infusion - maybe once a year?

[JørgenVarnæs]

er der kommet forståelige data omkring duration på CAR-T? Det kunne lyde som om der er udfordringer?

[Bulder]

BB2121 viste på asco lige under 1 år.

[JørgenVarnæs]

ja, det er sgu ikke meget - hvis det så oven I købet ikke kan bruges i 1st line

[Bulder]

Da det kun er 40% af MM-NDs der er egnede til asct, vil en fremtid med car-t EFTER asct begrænse car-t's anvendelse i 1. linje noget.

[Bulder]

Og så bliver det vel nærmest at regne for 2. linje

[E_L]

@15:52 it will take a whole lot of new trials to prove if that would work…

[E_L]

if we can some sort of confirmation that CAR-t is really not suited for first line, i think it make a lot of Dara-fans sleep better… Let's hope we hear more in the next months

[Bulder]

Yes, and only the part of pts that were young and strong enough to undergo an asct.

[Bulder]

Two very interesting vidoes, E L. If you combine them they say that you have to get rid of a lot of the MM-cels before(!) car-t works.

[E_L]

exactly! i certainly did not realise that before…

[E_L]

the split first dose is on the agenda of the CHMP meeting this week

[Plimsoller]

Does that mean another treatment e.g. Dara, is necessary prior to using CAR-T?

[E_L]

That is how I understand it, but I am a bit reluctant to deduct that from just those 2 articles, I am sure we willl learn more about it soon

[Plimsoller]

Ok. Thank you E L. One thing is for sure, and that is that you know a hell of a lot more about it than I do

[E_L]

haha, unfortunately Genmab is trying to prove to me that staying informed is not necesarily a guarantee for investment returns...

[JørgenVarnæs]

Jan on MAIA - https://www.berlingske.dk/virksomheder/genmab-topchef-foer-skaebnedag-det-kan-faa-kaempe-indflydelse-paa