Genmab — August 2018

[E_L]

Sequencing Through Multiple Lines of Therapy https://www.onclive.com/peer-exchange/myeloma-next-gen-regimens/sequencing-through-multiple-lines-of-therapy

[E_L]

Daratumumab in Primary Effusion Lymphoma
https://www.nejm.org/doi/full/10.1056/NEJMc1806295

[E_L]

Is immunotherapy cost-effective? http://www.oncologytube.com/video/is-immunotherapy-cost-effective/10004937

[Bulder]

Thx again E L for your vigorous research. Dara is establishing itself as soc after 1. relapse. Soon it will move up front.

[bibob]

Thx E L and Bulder. Sounds promising.

[Sukkeralf]

Thanks - somebody knows what the problem mentioned with BCMA is?

[Sukkeralf]

So, if somebody is not lenalidomide sensitive, there is really no on-label use of elotuzumab right now. I’m sure we’re going to get to this more, but the BCMA is now becoming an issue as well.

[gentogen]

Ved det ikke, men fandt dette: "a main concern, which is the possibility of CAR T–BCMA–induced immune editing whereby residual MM cells decrease their BCMA expression following CAR T cell infusion, enabling immune evasion. Therefore, using a dual- or even triple-targeting CAR could potentially overcome this problem and enhance the response rate to CAR T cell therapy"

[gentogen]

http://www.hematology.org/Thehematologist/Diffusion/8447.aspx

[pauly]

Godt nok en lav omsætning for tiden

[Helge_LarsenPI-redaktør]

Det må man sige.

[Investor13]

Nu hvor du er på Helge. Hvor stor en sandsynlighed vurderer du der er, på at MAIA fejler?

[pauly]

Hmmm den er lav men at sætte procenter på er godt nok svært, vi er bare enige om at gode tal er essentielle for salget fremover

[Parasitism]

Du er godt nok usikker i din Investor13 - synes du spørger om det ret ofte. Har du smidt en for stor del af din portofølge i GEN?

[Parasitism]

i din sag *

[Parasitism]

ift. hvad din risikovillighed kan bære

[henrik48]

Jeg tror at mange af os vil synes at vi er/har været for tunge i Genmab hvis MAIA fejler

[pauly]

Absolut for så har vi lavet i bukserne

[Investor13]

ja, ca. 50%. Men der fordi jeg tror på casen. Spekulerer bare om jeg skal reducere snart, inden MAIA data. Selvom jeg klart mest hælder til succes.

[Parasitism]

Jeg tør i hvert fald ikke tage hjem til konen, den dag, hvis MAIA mod mine forventninger skulle skuffe.