Genmab — August 2018

[gentogen]

Det fremgår af hjemmesiden for HOVON, af CD20xCD3 rekrutterer fra foreløbig en klinik i Rotterdam (for lige at følge op på iagttagelsen fra tidligere)

[gentogen]

De har en undergruppe, der arbejder med 'first-in-man' studier

[E_L]

so you think this is GCT3013-01 @gentogen ?

[Raffles]

Thanks Bulder, EL and Gentogen. Your input is highly appreciated:-)

[gentogen]

Det ved jeg med sikkerhed, at det er. Se EHA 23 Abstract: PF637 fra juni måned, hvor det hedder, at "The clinical safety of DuoBody-CD3xCD20 (GEN3013) in patients with B cell malignancies will be assessed in a first-in-human study."

[gentogen]

CD3 BISPECIFIC ANTIBODY SCREEN IDENTIFIES CD20 AS THE MOST EFFICIENT TARGET FOR ELIMINATION OF B CELL MALIGNANCIES; PRE-CLINICAL EVALUATION OF DUOBODY-CD3XCD20
Author(s): Patrick Engelberts , Ida Hiemsta , Joyce Meesters , Bart De Jong , Theodora Salcedo , Sandra Verploegen , Edward van den Brink , Danita Schuurhuis , Sjeng Horbach , Aran Labrijn , Paul Parren , Janine Schuurman , Esther Breij
EHA Learning Center. Engelberts P. Jun 15, 2018; 215079

[gentogen]

one of the CD3xCD20 BsAbs showed extraordinary potency and outperformed the other CD20-targeting BsAb as well as CD3 BsAbs against all other B cell targets tested. This BsAb, designated DuoBody-CD3xCD20, was shown in vitro to only activate T cells in the presence of B cells and to induce potent T-cell-mediated cytotoxicity of B cell lymphoma cell line

[gentogen]

https://learningcenter.ehaweb.org/eha/2018/stockholm/215079/patrick.engelberts.cd3.bispecific.antibody.screen.identifies.cd20.as.the.most.html?f=ce_id=1346*ot_id=19042*media=3

[E_L]

excellent

[E_L]

you know, some still think PI stands for ProInvestor, but I think Helge really meant Private Investigator lol

[Helge_LarsenPI-redaktør]

[Raffles]

lol EL:-) And we have a number of Sherlock Holmes amongst us! Well done.

[Bulder]

Tak gentogen. Gad vist om det er den "dæmpning" af cd3-armen, som Winkel snakkede om, som kun aktiverer T-celler, når der er (maligne) B-celler til stede?

[Bulder]

Lyder også lovende rent safety-mæssigt, at sc versionen "demonstrated lower peak cytokine levels".

[JørgenVarnæs]

Det er vel den egentlige nøgle til cd3cd20 koden

[Solsen]

Har en linket til Hovon ?

[Solsen]

Godt arbejde !

[gentogen]

Se punkt 3 samt linket i slutningen af det punkt (inklusionskriterier): http://www.hovon.nl/working-groups/working-groups/llpc.html

[Solsen]

Tak det prøver jeg

[peter12]

Jeg ved ikke om det er nyt at MOR202 udvikling i MM bliver stoppet ? https://www.morphosys.com/media-investors/media-center/morphosys-ag-reports-second-quarter-2018-financial-resultshttps://www.morphosys.com/media-investors/media-center/morphosys-ag-reports-second-quarter-2018-financial-results