Genmab — Juni 2018
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JV - nej median PFS ikke nået, se side 11 http://ir.genmab.com/static-files/883e0329-61cc-418c-8703-cf8cc8e010f1
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Resten er gemt, så der stadig er råd til en juicebrik, hvis alt andet fejler
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Jep - har set den. Men ifht cut off på 27 måneder på den graf er vi vel minimum ude i 33 måneder. Data er i hvert fald 6 måneder gamle
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Som GEN angiver er det ASH og fda application data i grafen
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OK. Men der ikke annonceret at median PFS er nået. Måske nye data på ESMO?
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Det må da også give onkologerne lidt hovedbrud, at Alcyone tilsyneladende performer bedre end den nuværende backbone 1st Line behandling i previously untreated
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Ptjaaah, der var jo ikke noget på asco. Måske den info skal bruges ifm forhandlinger efter ema godkendelse?
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this is in spanish, maybe @bibob can help, Informe de Posicionamiento Terapéutico de daratumumab (Darzalex
) en mieloma múltiple https://www.aemps.gob.es/medicamentosUsoHumano/informesPublicos/docs/IPT-daratumumab-Darzalex-mieloma-multiple-MM.pdf -
and i am just going to repost the article from Plesner from yesterday, as i think most will have missed it , Daratumumab for the Treatment of Multiple Myeloma , https://www.frontiersin.org/articles/10.3389/fimmu.2018.01228/full
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"If further substantiated that an implication may be that daratumumab should be part of any anti-myeloma treatment. Given the pleiotropic effects of daratumumab, it is in fact difficult to imagine how a myeloma patient can become truly refractory to daratumumab."
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@EL 10:47 Efter vurderingen af de økonomiske data anses det, at kombination af daratumumab og bortezomib og dexamethason er en værdifuld løsning hos modtagelige patienter, som har erfarne tilbagefald efter i det mindste forudgående behandling, mens kombinationen med lenalidomid og dexamethason ville være en mulighed for situationer, hvor behandling efter et andet tilbagefald.
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