Genmab — Juni 2018

[E_L]

• Perspective on CAR-T ; data from bluebird was really good, but also encouriging from our perspective because it is clearly not a cure; other drugs are still needed. Tumour can not be kept under control for longer then 1 year. Also sceptical about the patient population; different from what we see in our trials; much younger, much fitter; selected to endure this very agressive type of therapy.

[E_L]

• Probably for 3dr, 4th line setting, but IF they can get earlier lines, it will compete with stem cell transplantation, and need fit patients which tend to be 10% of the market (Dara patients often 60+/70+)

[E_L]

• “we were quite encouraged by that data” Sees Dara as “undisputed back bone combination therapy”

[E_L]

• CART has serious toxicity, patients spending 10 days or more in intensive care for very high prices, for relatively short lived control of the disease. “good luck with that” (lol)

[E_L]

• Admits Glaxo has very good BCMA drug, SC Dara very close. Glaxo eye toxicity problems. Potential for Dara Glaxo combi

[E_L]

• Repeated that chair time / long infusion time is still an issue in the US and expects a lot from SC (“massive impact”)

[E_L]

• Also that SC seems to show better effect as IV so far and much better tolerated. Filing 2019. Janssen wants to file together to get a broad label approval for SC.

[E_L]

• 1 more TV study to launch in H2 in ‘another’ solid cancer. Which one?

[Sukkeralf]

Hi EI - regarding "- Admits Glaxo has very good BCMA drug, SC Dara very close. Glaxo eye toxicity problems. Potential for Dara Glaxo combi" i remember it as the GSk patients have been through more lines of therapi (more sick)

[Sukkeralf]

and the same goes when comparing sc mono vs Iv mono - IV patients more sick

[Sukkeralf]

For me sc dosing is still mostly about convenience and longer patent life and even maybe higher price - but hopefully we will see better efficacy in the larger trials as well

[E_L]

yes, i guess we need more trial data on that. Jan seemed to think for SC it could have something to do with dosing , the way he spoke about it , it feels like he believes SC could indeed be better. Lets hope so

[GeorgeBest]

Lidt statistik til sammenligning: Bugspytkirtelkræft 48000 nye tilfælde per år i USA. MM 30000 nye tilfælde per år

[E_L]

o really? thought it was smaller. just imagine what would happen if that works…

[Bulder]

Sukker, i attakvis sclerose har man lange perioder i bedring. Og de sundhedsfaglige fraråder ikke graviditet: "Til kvinder, der planlægger graviditet inden for de nærmeste år, anbefales dog dimethylfumarat som førstevalg." i stedet for teriflunomid https://pro.medicin.dk/sygdomme/sygdom/318380

[Sukkeralf]

Så er aktien endelig i plus

[Sukkeralf]

Ok tak bulder

[Bulder]

Nice abstract E L. Should have known before listening myself

[E_L]

lol

[E_L]

http://investor.seattlegenetics.com/phoenix.zhtml?c=124860&p=RssLanding&cat=news&id=2354368 Seattle Genetics Announces First Patient Dosed in Phase 2 Trial of Tisotumab Vedotin for Women with Recurrent or Metastatic Cervical Cancer