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Genmab — Juni 2018

Planlagt Fastgjort Låst Flyttet Genmab
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  • G Offline
    G Offline
    GeorgeBest
    wrote on sidst redigeret af
    #257

    Hvad jeg får ud af at læse på Twitter, er at bb2121 er rigtig godt når alt andet inclusive dara er prøvet. Altså mindst 5-6 linie behandling. Patienterne har her ikke andre muligheder end CAR-T.

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    • P Offline
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      Plimsoller
      wrote on sidst redigeret af
      #258

      Ok. Tak.

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      • E Offline
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        E_L
        wrote on sidst redigeret af
        #259

        i remember reading that they have been very carefull in selecting their patients, also they are relatively young, the selection process apparantly took very long; is that what you were asking @
        Plimsoller ?

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        • G Offline
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          GeorgeBest
          wrote on sidst redigeret af
          #260

          Men BLUE og CELGENE vil givetvis gøre alt for at få det frem til mindst 3. linie. Ellers bliver deres investeringer aldrig rentable. Og så kan det jo tage noget fra dara

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          • G Offline
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            GeorgeBest
            wrote on sidst redigeret af
            #261

            Men generelt tror jeg ikke vi behøver frygte et CAR-T hype som vi sà efter ASH

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            • P Offline
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              Plimsoller
              wrote on sidst redigeret af
              #262

              Yes EL. Thank you. It was to assess whether it was an even playing field concerning the outcome of the trials. If the selection process is very biased it is certainly something to consider.

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              • E Offline
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                E_L
                wrote on sidst redigeret af
                #263

                have you seen the $ number EP Vantage put on bb2121? only
                $760mio in 2024....

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                • P Offline
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                  Plimsoller
                  wrote on sidst redigeret af
                  #264

                  @GB. Ja der er ikke noget at sige til at de vil frem i verden, men det skal jo være pga.et godt produkt, og ikke pga. hype.

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                  • P Offline
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                    Plimsoller
                    wrote on sidst redigeret af
                    #265

                    Yes. It is very little and very late - and furthermore based

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                    • G Offline
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                      GeorgeBest
                      wrote on sidst redigeret af
                      #266

                      Enig. Men de vil gøre alt for at forsvare deres investering.

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                      • P Offline
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                        Plimsoller
                        wrote on sidst redigeret af
                        #267

                        on a very futuristiske assessment.

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                        • P Offline
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                          Plimsoller
                          wrote on sidst redigeret af
                          #268

                          Det forstår jeg godt, men data er med dara indtil videre:)

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                          • G Offline
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                            GeorgeBest
                            wrote on sidst redigeret af
                            #269

                            CELGENE har jo satset vildt på CAR-T. De betalte også milliarder for Juno

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                              GeorgeBest
                              wrote on sidst redigeret af
                              #270

                              CELGENE betalte 9 milliarder USD for Juno. Sanseløst...

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                              • B Offline
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                                bibob
                                wrote on sidst redigeret af
                                #271

                                Dara er et veltolereret MM drug og fortsætter med at bevise sit potientiale. CAR-T skal tilpasses den enkelte patient og vil være ( hvis det kommer helt frem i linierne ) alt for dyrt og som flere gange skrevet af dygtige skribenter her på sitet sandsynligvis kun til meget alvorligt angrebne patienter som ikke har andre muligheder. Sundhedssystemerne i de enkelte lande har jo ikke ubegrænsede midler til rådighed.

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                                • E Offline
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                                  E_L
                                  wrote on sidst redigeret af
                                  #272

                                  Niels van de Donk presentation on twitter https://twitter.com/mtmdphd/status/1002989064449069056 - https://twitter.com/mtmdphd/status/1002989447493967872 - https://twitter.com/mtmdphd/status/1002989970515259400

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                                    E_L
                                    wrote on sidst redigeret af
                                    #273

                                    no further explanation on Dara/Atezo though

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                                    • G Offline
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                                      GeorgeBest
                                      wrote on sidst redigeret af
                                      #274

                                      Hidtil er konsensus på ASCO også at CAR-T er rigtig godt til de meget sene linier. Jeg har ikke set onkologer eller lign argumentere for at det skal frem

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                                      • P Offline
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                                        Plimsoller
                                        wrote on sidst redigeret af
                                        #275

                                        Ok. Lad os håbe at nogle af CAR-T
                                        pengene kommer tilbage til Genmab.

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                                        • E Offline
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                                          E_L
                                          wrote on sidst redigeret af
                                          #276

                                          Barclays: Key takeaways from multiple myeloma physician dinner on BCMA CAR-T http://www.twitlonger.com/show/n_1sqi5um

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