Genmab — Maj 2018
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Det bliver der bibob.
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the extent of cell lysis was highest with ofatumumab, followed by rituximab and ocrelizumab. Ongoing studies in other B-cell cytotoxicity assays will provide a broader overview regarding relevant MoAs.
Conclusions: The strong complement-dependent B-cell lysis by ofatumumab may contribute to its high potency in vivo that enables a low-dose subcutaneous dosing regimen.
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EMA:
The Paediatric Committee (PDCO) adopted opinions agreeing paediatric investigation plans (PIPs) for the following medicines:
• Daratumumab, EMEA-002152-PIP01-17, from Janssen-Cilag International N.V., for the treatment of lymphoid malignancies (except mature B-cell neoplasms); http://www.ema.europa.eu/docs/en_GB/document_library/Committee_meeting_report/2018/05/WC500248882.pdf -
Recommendations for submission of supplementary information for Dara, signal Encephalopathy, to Assess in the next PSUR (submission by 24 July 2018) - http://www.ema.europa.eu/docs/en_GB/document_library/PRAC_recommendation_on_signal/2018/04/WC500247424.pdf p8
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another Tecentriq disappointment in colorectal cancer https://www.reuters.com/article/us-roche-immunotherapy/setback-to-roche-hopes-for-tecentriq-as-fails-key-cancer-trial-idUSKBN1IB16N
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God morgen.
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God morgen
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interesting interview on the MASTER trial - https://myelomacrowd.org/full-show-master-trial/
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Danke vel
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