Genmab — November 2017
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Quote: Darzalex is likely to be used in combination with Celgene's leading multiple-myeloma drug, Revlimid, which is slated to have sales of $12 billion in 2021. Genmab earns a tiered royalty on Darzalex sales, with the highest rate of 20% payable on net sales above $3 billion achieved in a calendar year. (08/16/17)
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Plesner kørte sit eget lille ISS-studie ovre i Vejle med 4 pts, men med et interessant formål: Daratumumab is a new treatment for patients with myeloma. While many patients benefit from this treatment some do not and the mechanism(s) of failure are poorly understood. This study aims to clarify aspects of resistance to treatment with daratumumab in order to improve patient outcomes in the future.
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Dette studie er nu afsluttet https://clinicaltrials.gov/ct2/show/NCT02419118?term=daratumumab&cntry1=EU%3ADK&rank=1
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Mere grus i maskineriet for PD-1 og PD-L1: http://onkologisktidsskrift.dk/behandlinger/660-kraeftbehandlinger-medforer-reumatologiske-sygdomme.html
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Ingen "roser uden alvorlige torne" i den terapi.
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I øvrigt måske en ide at følge med i Myelomatosebladet. Myelomatoseforeningen har i torsdags haft seminar, hvori bl.a. indgik et foredrag af Nicolai Grønne fra Herlev om Vaccination og CAR-T imod Myelomatose. Der plejer at kommer omtale med slides i bladet efterfølgende. Nogen gange har de også optaget videoer. Det ville jo være det bedste. https://www.myelomatose.dk/content/uploads/2017/08/Myelomatosebladet-Sep-2017.compressed.pdf
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Plesner: "På sigt bliver det sandsynligvis muligt selv
at tage sin Daratumumab hjemme under
huden i mavefedtet ved hjælp af en pumpe." Fra maj-nummeret af myelomatosebladet s. 19. https://www.myelomatose.dk/content/uploads/2017/05/Myelomatosebladet-Maj-2017-hjs.compressed.pdf -
Har fået bekræftet fra Myelomatoseforeningen at alle foredrag på konferencen i torsdags er optaget på video og vil blive lagt på deres hjemmeside, så snart de er færdigredigerede. Så inden længe kender vi Herlevs syn på CAR-T imod myelomatose. Herlev er i forvejen fremme i skoene i CAR-T mod modermærkekræft.
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Tusinder tak Bulder.
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With FDA Approval for Advanced Lymphoma, Second CAR T-Cell Therapy Moves to the Clinic https://www.cancer.gov/news-events/cancer-currents-blog/2017/yescarta-fda-lymphoma
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