Genmab — Juli 2017
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Ja. This trial will assess the safety and efficacy of an induction therapy using the combination of dexamethasone, lenalidomide (revlimid), daratumumab (Darzalex) and carfilzomib (Kyprolis) to treat patients with newly diagnosed multiple myeloma. The therapy with KRdD (Kyprolis, Revlimid, dexamethasone, Darzalex) will be followed by autologous hematopoietic cell transplantation (auto-HCT) and KRdD consolidation.
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Indtil nu har vi ikke hørt, at der er nogen der er kureret af dara og taget af behandling - så maintenance i 5-10 for mange der behandles first line vil skæppe godt i kassen. Antallet af second- og senere linier vil mindskes i de kommende år, hvis first line kommer ud med mega succes.
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US integrated Darzalex sales figures for June have been released by Symphony Health Solutions. Darzalex sales were USD 81.5m in June versus USD 80.3m in May. These numbers are similar to the institutional sales numbers released by Symphony last week.
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Fra Nordea: We expect Darzalex sales to accelerate in H2 2017, fuelled by increased penetration in second-line MM, the label expansion with Pomalyst in the US, and additional launches in Europe with a much broader second-line label. The traction in the second-line setting is likely to be the main driver for a further acceleration in sales.
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CLL cells opsonized with hexamerization-enhanced CD20 mAb Hx-7D8 are rapidly killed by CDC in the complete absence of C9, suggesting that assembly of small C5b-8 pores is sufficient for CDC. This finding supports the potential for future use of hexamer-formation enhanced mAbs in cancer immunotherapy.
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Det kynne tyde på at hexa-cd20 kunne gøre rituximab/imbruvica rangen stridig...
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...men det er jo altsammen ligegyldigt, da Carnegie har fortalt os, at GEN kan glemme alt om omsætning uden for Dara
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arrzhex...
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Vedr. besøg i Genmabs nye lokaliteter i Holland kan det først blive i starten af 2018. Indflytning forventes nemlig først sidst i 2017.
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