Genmab — Juli 2017
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LY3164530
LY3164530 is a bispecific anti-EGFR/cMET antibody generated by fusing an anti-EGFR single-chain variable fragment (humanized cetuximab sequence) to the N-terminus of the emibetuzumab heavy chain. LY3164530 binds and internalizes cMET and EGFR without agonistic activity. In a NSCLC xenograft model, LY3164530 showed better antitumor efficacy than combination treatment with emibetuzumab and cetuximab.32 A phase I clinical study is ongoing (NCT02221882).
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JNJ-61186372
The bispecific EGFR/cMET antibody JNJ-61186372 is a heterodimeric IgG1 composed of two units targeting EGFR and cMET.33 The cMET-binding IgG1 molecule is generated with a K490R mutation in the CH3 domain and the EGFR-binding IgG1 molecule is generated with a F405L mutation in the CH3 domain.
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With these IgG1 molecules, heterodimeric IgG is produced using the controlled Fab-arm exchange method.34 JNJ-61186372 inhibits tumor cell growth by the downregulation of both EGFR and cMET in combination with enhanced antibody-dependent cell-mediated cytotoxicity.33, 35, 36, 37 Patients with NSCLC with EGFR mutations are being recruited for a phase I clinical study (NCT02609776).
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Tja - mærkelig aktie. A/B handler mest med sig selv, og DK løber skrigende ud af aktien i dag. Er selv godt tanket op i GEN i den lange aktieskuffe, og mi
ne GEN er ikke til salg. -
@Pensionisten - ja, måske lidt/vel overdrevet, og det er ganske korrekt, at det er meget tyndt marked. Jeg er fundamental investor, og ser en god case. Forstår så ikke, hvorfor nogen overhovedet sælger i dette niveau. Det er så min strategi, og andre har selvfølgelig deres, alt respekt for det.
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Tyndejner: De få der sælger kan f.eks. bare være nogen som i en periode vil omlægge lidt til andre papirer eller skal have lidt lommepenge til ferien.
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Jeps...og et sundhedstegn at de ikke kan gøre det uden kursen stiger.
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