Genmab — April 2017
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Our data further show that Dara activates but does not induce apoptosis in CD38(-) NK cells. Thus, we hypothesize that the combination of Dara and CD38(-) CS1-CAR NK cells can show a synergistic effect on tumor eradication and prevention of MM relapse. Our data indeed demonstrated that the combination of CS1 CAR NK cells with CD38(-) NK cells but not with CD38+ NK cells shows a synergistic effect to eradicate MM cells
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Both CS1 and CD38 are tumor-associated antigens expressed on the surface of MM cancer stem-like cells, suggesting that dual targeting of CS1 and CD38 may prevent relapse. Thus, we investigated the combination therapy with Dara and CS1-CAR NK cells for the treatment of relapsed MM.
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Overall, we have found Dara was effective in 4 of 6 evaluable non-ETP T-ALL samples. In summary, we found dara is a highly effective novel monotherapy for T-ALL in preclinical models. Based on these results, we are developing an early phase trial for children and young adults with relapsed/refractory T-ALL.
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By inducing the expression of CD38, SY-1425 in combination with DARA elicits tumor cell death and NK cell activation. Based on these findings, a phase 2 clinical study with SY-1425 in combination with an anti-CD38 antibody is planned in AML using an RARA biomarker patient selection strategy.
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The combination of SY-1425 and DARA led to a six-fold increase in tumor cell death relative to the single agent controls, and 5-10 fold increases in NK cell activation is observed only in the SY-1425 and DARA combination treatment of RARA-high AML cell lines.
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Hold da op. Du har haft travlt gentogen. Så hvad har vi nu? Et præklininsk studie, der påpeger synergi mellem dara og CS1-CAR NK celler i MM. Og dara mono i T-ALL. Et fase 1 studie er planlagt. Samt en kombination af SY-1425 og dara i AML. Et fase 2 studie er planlagt.
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good find again. we discussed the middle one, SY-1425, on the back of a Yahoo article last week, i think Thursday. It must be this study that they will expand to include Dara: https://clinicaltrials.gov/ct2/show/NCT02807558?term=NCT02807558&rank=1
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