Genmab — Marts 2017
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NKTCL. Se vedlagte link som en genopfrisker på daratumumabs fantastiske muligheder på virkning i NKTCL http://www.nejm.org/doi/full/10.1056/NEJMc1605684#t=article
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Udgangspuntet var: Due to relatively high expression of the complement inhibitors and lower CD38 expression levels compared to MM cells, daratumumab failed to effectively induce CDC in most patient‐derived NHL and CLL cells 133, 134. Nevertheless, daratumumab and isatuximab showed a marked anti‐tumor activity in mouse xenograft models of NHL in vivo 63, 64, 134. Based on these results, daratumumab is being evaluated in a phase 2 clinical trial in patients with CD38‐positive mantle cell lymphoma,
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