Genmab — September 2016
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Dr. Metha samler op på artiklen i Blood fornylig på en måde så selv jeg kan forstå noget af det. http://www.oncotherapynetwork.com/hematologic-cancer-targets/daratumumab-may-exert-indirect-effects-multiple-myeloma
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Fedt Bulder.
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Vi glæder os
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What they found was that daratumumab helped improve the tumor microenvironment by enhancing the immune response. So daratumumab actually reduced T-regulator cells, MDSCs and B-regulatory cells at the same time that it helped expand helper and cytotoxic T cells. The authors’ elegant work also showed that not only was there expansion of the effector and helper T cells, but there was also an increase of functional activity of these cells. These immune cells had more alloreactive functions and the -
alloreactive functions and the authors confirmed that these cells were clonal by using a T-cell clonality assay. So in this setting, what I see a similar thing as we see with immune checkpoint inhibitors, which is immune enhancement.
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"f this antibody is mobilizing the immune system in a way that it reduces the B- and T-regulatory cells [that inhibit T-cell function] and MDSCs, whether it can be another immune checkpoint inhibitor and whether we can combine it with other antibodies or cytotoxic therapies in various other solid tumors is [an open question]. I see that in the future we will see these types of studies with daratumumab".
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