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Genmab — Maj 2016

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • CeletusC Offline
    CeletusC Offline
    Celetus
    wrote on sidst redigeret af
    #2217

    Tror du har ret Bulder. Af hvad jeg kunne finde, så er der et par papirer derude der konkluderer at EGFR-mutationen er mere udbredt blandt koreanere, hvorfor de er en oplagt testgruppe.

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    • J Offline
      J Offline
      JKY_VH
      wrote on sidst redigeret af
      #2218

      Jamen, hvad venter vi så på?

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      • BulderB Offline
        BulderB Offline
        Bulder
        wrote on sidst redigeret af
        #2219

        Kan være at vi venter på at finde den rette tyrosin-kinase-hæmmer at kombinere med, hvis nu EGFR-mutationer er et tema i studiet. Det var også det Solsen foreslog tidligere.

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        • S Offline
          S Offline
          Sukkeralf
          wrote on sidst redigeret af
          #2220

          Men JNJ372 skal vel først køres alene for at fastslå safety?

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          • BulderB Offline
            BulderB Offline
            Bulder
            wrote on sidst redigeret af
            #2221

            Winkel blev spurgt direkte på Q&A og svarede: We anticipate patients to enter this study shortly.

            1 Reply Last reply
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            • BulderB Offline
              BulderB Offline
              Bulder
              wrote on sidst redigeret af
              #2222

              I den detaljerede beskrivelse på CT står der: In Part 2, participants with documented epidermal growth factor receptor (EGFR) mutations and measurable disease, whose disease has progressed during treatment with a marketed EGFR inhibitor, will be enrolled and receive JNJ-61186372 at the RP2D determined in Part 1. Så hvis de mutationer er særligt udbredt blandt koreanere, er det nok derfor.

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              • BulderB Offline
                BulderB Offline
                Bulder
                wrote on sidst redigeret af
                #2223

                Sukker: Nej, og hvis formålet også er at assess the preliminary efficacy of JNJ-61186372. Det kan man jo heller ikke se, hvis man kombinerer med noget andet.

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                • SolsenS Offline
                  SolsenS Offline
                  Solsen
                  wrote on sidst redigeret af
                  #2224

                  Nej første del er jo sikkert dosing, men interessant at se hvor effeftiv en kombination, måske kan være. 100 % Regression af store tumore er stærkt.

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                  • G Offline
                    G Offline
                    gentogen
                    wrote on sidst redigeret af
                    #2225

                    The PIONEER study, published in the February issue of the Journal of Thoracic Oncology, tested 1482 patients from 7 Asian regions, and found EGFR mutations at a rate of 51.4% overall. Previous estimates have put the rate at around 30% in Asian patients, and around 20% among white patients.

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                    • G Offline
                      G Offline
                      gentogen
                      wrote on sidst redigeret af
                      #2226

                      The finding suggests that about half of Asian patients with NSCLC have EGFR mutations, and so are candidates for EGFR-targeted therapies such as erlotinib (Tarceva) and gefitinib (Iressa) and similar agents.

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                      • G Offline
                        G Offline
                        gentogen
                        wrote on sidst redigeret af
                        #2227

                        Så ja. God forklaring på Korea. Og med den nye artikel ser studiet jo også særdeles velunderbygget ud. Så vi kan jo bare under os over, hvad vi venter på...

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                        • G Offline
                          G Offline
                          gentogen
                          wrote on sidst redigeret af
                          #2228

                          Link Preview Image
                          EGFR Mutations Found in Half of Asian NSCLC Patients

                          The first epidemiologic study of EGFR mutations in Asian patients with adenocarcinoma non-small cell lung cancer (NSCLC) has found a rate of 51.4%.

                          favicon

                          Medscape (www.medscape.com)

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                          • Helge_LarsenPI-redaktørH Offline
                            Helge_LarsenPI-redaktørH Offline
                            Helge_LarsenPI-redaktør
                            wrote on sidst redigeret af
                            #2229

                            Sukkeralf...Har du spørgsmål til Zealand Pharma, så må du godt stille dem senest kl. 11 i morgen.

                            1 Reply Last reply
                            0
                            • J Offline
                              J Offline
                              JKY_VH
                              wrote on sidst redigeret af
                              #2230

                              Mon det bliver til et gensyn med 1200 i dag? Vi har i hvert fald været tæt på:-)

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                              • Helge_LarsenPI-redaktørH Offline
                                Helge_LarsenPI-redaktørH Offline
                                Helge_LarsenPI-redaktør
                                wrote on sidst redigeret af
                                #2231

                                Mon Nordnet kan trække den tur alene?

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                                0
                                • J Offline
                                  J Offline
                                  jkj
                                  wrote on sidst redigeret af
                                  #2232

                                  Nyt fra Don. My sweeties and I bought a nice bouquet of yellow roses to celebrate my latest treatment results. These numbers are the lowest that I have seen in my 13 years with myeloma.http://myelomahope.blogspot.de/2016/05/yellow-roses.html

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                                  • Helge_LarsenPI-redaktørH Offline
                                    Helge_LarsenPI-redaktørH Offline
                                    Helge_LarsenPI-redaktør
                                    wrote on sidst redigeret af
                                    #2233

                                    Vidunderligt. Får en klump i halsen.

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                                    0
                                    • J Offline
                                      J Offline
                                      jkj
                                      wrote on sidst redigeret af
                                      #2234

                                      ja ikke

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                                      • J Offline
                                        J Offline
                                        JKY_VH
                                        wrote on sidst redigeret af
                                        #2235

                                        Fantastisk, man får kuldegysninger på den gode måde:-)

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                                        • P Offline
                                          P Offline
                                          pauly
                                          wrote on sidst redigeret af
                                          #2236

                                          dejligt

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