Genmab — Januar 2016
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Svært stof, men afsluttende citat: Interestingly, the E345K and E430G mutations, introduced into CD20 mAb 7D8, provided strongly enhanced CDC of patient cells (Fig 7). Moreover, both mutations enabled killing of 5 out of 6 patient CLL cells by RTX, where wild-type RTX was unable to induce CDC.
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IgG1 backbones with preferred mutations E345K or E430G conveyed a strong ability to induce conditional complement-dependent cytotoxicity (CDC) of cell lines and chronic lymphocytic leukemia (CLL) patient tumor cells, while retaining regular pharmacokinetics and biopharmaceutical developability
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Developing Antibody-Drug Conjugates for the Treatment of Solid Cancers
Antibodies i Kina: Parren PaulPaul W.H.I. Parren, Ph.D., Senior Vice President & Scientific Director, Genmab. http://www.pegsummitchina.com/cancer-biotherapeutics/ -
Chemical engineering of antibodies, fueled by recent molecular insights, is providing important opportunities for the development of more potent antibody therapeutics. The progress in two antibody-drug conjugate programs from Genmab’s portfolio will be highlighted.
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Genmab har i det hele taget gang i ADC: Our method enables functional screening of large antibody libraries to identify therapeutic antibody candidates with internalization characteristics favorable for the development of ADCs. http://jbx.sagepub.com/content/21/1/12.abstract?rss=1
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http://www.fool.com/investing/general/2016/01/12/johnson-johnsons-ceo-just-tipped-his-cap-in-a-big.aspx?source=eogyholnk0000001&utm_content=buffer68abe&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer Darzalex den første i en række af blockbusters til JNJ
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Tak for link solsen. Exciting Stuff. Og US ser ud til at stabilisere sig.
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Tak Solsen.
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det her link er hellere ikke så dårligt http://www.mmm-online.com/pipeline/new-multiple-myeloma-drugs-prompt-cost-effectiveness-report/article/464497/
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Nu går Obama ind i kampen: http://www.theguardian.com/us-news/2016/jan/12/obama-state-of-the-union-address-2016-cancer-cure-initiative
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