Genmab — Januar 2016
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Imens Udvikler J&J videre på det bedste stof der har potentialet til at lave et paradigmeskift og revolutionere markedet, samtidig med at google i 2025 har deres robotgravere klar. Spændende tid og vi må håbe at det lykkedes at gennembryde pansret for en af dem. Det er sjovt at tænke sig hvor langt forskningen ville være kommet i offentlig regi som socialisterne med Hillary i spidsen higer efter. De slås jo nærmest om at nå målet først de forskellige storspillere, dejligt med konkurrence.
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Mere nyt om Hexa:A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface. http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002344
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Svært stof, men afsluttende citat: Interestingly, the E345K and E430G mutations, introduced into CD20 mAb 7D8, provided strongly enhanced CDC of patient cells (Fig 7). Moreover, both mutations enabled killing of 5 out of 6 patient CLL cells by RTX, where wild-type RTX was unable to induce CDC.
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IgG1 backbones with preferred mutations E345K or E430G conveyed a strong ability to induce conditional complement-dependent cytotoxicity (CDC) of cell lines and chronic lymphocytic leukemia (CLL) patient tumor cells, while retaining regular pharmacokinetics and biopharmaceutical developability
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