Genmab — April 2015
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TF-ADC demonstrated effective killing against tumor cell lines with variable levels of target expression. In xenograft models, TF-ADC was relatively potent in reducing tumor growth compared to EGFR- and HER2- ADCs. We hypothesize that the constant turnover of TF on tumor cells, makes this protein specifically suitable for an ADC approach.http://www.ncbi.nlm.nih.gov/pubmed/25724665
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J&J fokuserer på farma frem for medico
Medicinaldivisionen går fremad, mens Johnson & Johnson må se koncernens medicodivision tage et tocifret dyk. Det kan få giganten til at skære medicoaktiviteterne ned.
(medwatch.dk)
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ja vi får abstract release + J&J R&D dag
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Jeps. Har været i møder hele dagen. Ser nu rødt..Men Genmab klarer sig fint.
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BMY har i dag meddelt at de stopper et fase 3 med opdivo. MedWatc skriber at stoffet - et pd-1 hæmmer antistof forventes at omsætte for 5,7 mia usd allerede i 2019. Gamle Medarex ejere må græmme sig endnu engang for den foræring bmy fik for år tilbage - sølle 2 mia usd for Genmabs moder
http://www.natap.org/2007/HCV/103007_01.htm -
...vel at mærke stoppet førtidigt pga god effekt http://finance.yahoo.com/news/bristol-myers-big-drug-study-142312369.html
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Vejle hospital laver nyt studie med Daratumumab (!). "Monoclonal Antibodies for Treatment of Multiple Myeloma. Emphasis on the CD38 Antibody Daratumumab " (DARA)https://clinicaltrials.gov/ct2/show/NCT02419118?term=daratumumab&rank=5&submit_fld_opt=
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The effector mechanisms of daratumumab have been extensively studied in vitro, but the in vivo correlates and key determinants of success or failure when daratumumab is used alone or in combination with lenalidomide for treatment of patients with myeloma have not been clarified.
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There is potentially a wide spectrum of factors that may influence the quality and duration of response following treatment with daratumumab. The integrity of the patient's immune system may be important. Prior lines of chemotherapy or the myeloma disease itself may impair humural (i.e. complement) or cellular (i.e. ADCC) effector mechanisms that are of importance for the response to daratumumab.
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