Genmab — April 2014
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Humax-TF-ADC på ASCO ? er du sindsyg. Rachel sagde til mig vi skulle være heldige hvis vi skulle se data på ASH
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de har vel kun behandlet patienter i de meget meget lave dosis pt. ? de starter jo i de meget lavea dosis pga. giftigheden. så tror ASH er mere sandsynlig da vi så har nogle data fra lidt højere dosis og forhåbentlig nogle responser
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Importantly, JNJ-61186372 effectively inhibited tumor growth in models with mutant EGFR and cMet activation, whereas single agent EGFR inhibitors were less effective. The preclinical data support the clinical development of JNJ-61186372 in patients with lung cancer and other malignancies associated with aberrant EGFR and cMET signaling.
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We have designed a bispecific EGFR-cMet antibody (JNJ-61186372) with a unique set of mechanisms of action resulting in anti-tumor activity in the EGFR mutant setting, with or without cMet pathway activation. We have demonstrated three mechanisms of action that contribute to the activity of JNJ-61186372: 1) inhibition of ligand-induced phosphorylation of both EGFR and cMet, 2) receptor degradation in vivo, and 3) enhanced ADCC activity.
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jeg gav godt vide hvor langt JNJ-61186372 er fra at lave en IND
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Spændende. Det lyder som en kommende IND, så er vi også flyvende indenfor bispecifikke antistoffer
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En IND der og så en IND på Unibody med Lundbeck indenfor 12 måneder så er jeg en glad mand igen
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