Genmab — Januar 2014
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Og denne:Pts with CLL who have early stage disease (Rai 0-II) but have high-risk prognostic markers such as deletion 17p or deletion 11q have an increased risk of disease progression. Currently, these pts are offered watch-and-wait approach. The objective of this Phase II study is to evaluate the efficacy of ofatumumab in treating these pts with the goal to delay time to first chemoimmunotherapy treatment
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Mere endnu: Conclusions The O-dex regimen shows relatively high ORR and CR, with promising findings for PFS and OS (including pts. harboring p53 defects), as compared to published data on rituximab plus dexamethasone regimen or ofatumumab in monotherapy.
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sorgløs... hmmm...
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ja, på dage som disse her i 2014 glemmer man lidt at det ikke altid er sorgløst at være GEN'er
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well - og så alligevel ikke. Det er sgu da lidt af en reversal GEN laver på en positiv dag. Forhåbentlig ikke dårlige nyheder på vej...
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wouw - her er forklaringen - Pharmacyclics Inc. (PCYC: Quote) announced Tuesday morning that an Independent Data Monitoring Committee unanimously recommended that the Phase III RESONATE study, PCYC-1112-CA, a head-to-head comparison of IMBRUVICATM versus ofatumumab, be stopped early because the primary and a key secondary endpoint of the study have been met
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primary endpoint var en sammenligning af pfs - http://clinicaltrials.gov/show/NCT01578707
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