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Genmab — September 2013

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • G Offline
    G Offline
    gentogen
    wrote on sidst redigeret af
    #106

    ofatumumab in combination with bendamustine
    is an effective and tolerable therapy, providing high response rates
    and an acceptable safety profile for patients with either previously
    untreated CLL who are inappropriate for fludarabine-based therapy,
    or patients with relapsed CLL

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    • G Offline
      G Offline
      gentogen
      wrote on sidst redigeret af
      #107

      Investigator-assessed ORR was 95% (CR rate 43%) in the previously
      untreated population and 74% (CR rate 11%) in the relapsed
      population. 56% of patients in the in the previously untreated
      population who had an investigator-assessed CR

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      • G Offline
        G Offline
        gentogen
        wrote on sidst redigeret af
        #108

        No deaths were reported in the previously untreated population a

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        • D Offline
          D Offline
          deleted-user
          wrote on sidst redigeret af
          #109

          hvor kommer den poster fra?

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          • D Offline
            D Offline
            deleted-user
            wrote on sidst redigeret af
            #110

            jeg synes cr er rigtigt stærke

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            • G Offline
              G Offline
              gentogen
              wrote on sidst redigeret af
              #111

              Genmabs hjemmeside. Der er lidt forskellige udregninger af CR, men generelt ser det godt ud, ja. Jeg har endnu ikke nærlæst.

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              • G Offline
                G Offline
                gentogen
                wrote on sidst redigeret af
                #112

                se under events eller under investor downloads

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                • G Offline
                  G Offline
                  gentogen
                  wrote on sidst redigeret af
                  #113

                  http://ir.genmab.com/downloads.cfm

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                  • D Offline
                    D Offline
                    deleted-user
                    wrote on sidst redigeret af
                    #114

                    tak

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                    • bongobobB Offline
                      bongobobB Offline
                      bongobob
                      wrote on sidst redigeret af
                      #115

                      Dobbelt op på CR ifht Rituximab http://www.ncbi.nlm.nih.gov/pubmed/22869884

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                      • J Offline
                        J Offline
                        JKY_VH
                        wrote on sidst redigeret af
                        #116

                        aka, tak for feedback omkring sandsynligheder i fase 3. Det understreger min pointe nemlig, at det ikke er rimeligt at sætte sandsynligheden = 0 🙂

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                        • JørgenVarnæsJ Offline
                          JørgenVarnæsJ Offline
                          JørgenVarnæs
                          wrote on sidst redigeret af
                          #117

                          er det ikke de data Jan sagde at GEN ville præsentere på iwcll i Køln? Det ser dælme godt ud!

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                          • bongobobB Offline
                            bongobobB Offline
                            bongobob
                            wrote on sidst redigeret af
                            #118

                            Hvis man ser på Previously untreatet delen må man kunne forvente noget tilsvarende for det ph3 studie vi fik top line for i maj

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                            • MadsSkjernM Offline
                              MadsSkjernM Offline
                              MadsSkjern
                              wrote on sidst redigeret af
                              #119

                              JV, det er data fra ofa-bendamustine fase 2. De data han har lovet, men flyttet til ASH er ofa-clorambucil

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                              • MadsSkjernM Offline
                                MadsSkjernM Offline
                                MadsSkjern
                                wrote on sidst redigeret af
                                #120

                                Men samme indikation.

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                                • S Offline
                                  S Offline
                                  Sukkeralf
                                  wrote on sidst redigeret af
                                  #121

                                  Bendamustine er mere effektiv kemo end chlorambucil, men har også flere alvorlige bivirkningen

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                                  • JørgenVarnæsJ Offline
                                    JørgenVarnæsJ Offline
                                    JørgenVarnæs
                                    wrote on sidst redigeret af
                                    #122

                                    Hej MAds - der var oprindeligt to datasæt på iwcll - og ofa+chlorambucil fase III blev flyttet mens bendamustine blev på iwcll - som jeg husker det

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                                    • S Offline
                                      S Offline
                                      Sukkeralf
                                      wrote on sidst redigeret af
                                      #123

                                      Nemlig

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                                      • MadsSkjernM Offline
                                        MadsSkjernM Offline
                                        MadsSkjern
                                        wrote on sidst redigeret af
                                        #124

                                        OK

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                                        • MadsSkjernM Offline
                                          MadsSkjernM Offline
                                          MadsSkjern
                                          wrote on sidst redigeret af
                                          #125

                                          Iøvrigt godt at se god effekt af ofa-bendamustine, kombinationen testes i rituximab refraktær NHL fase 3 (ligesom GA101)

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