Genmab — December 2012
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[0553] FIG. 12 shows that while none of the individual EGFR antibodies and none of the cross-blocking combinations triggered CDC, most of the non cross-blocking combinations led to significant CDC on A431 cells (12a) and all non cross-blocking combinations led to significant CDC on A1207 cells (12b).
[0554] FIG. 13 shows CDC of A431 (13a) and A1207 (13b) cells in correlation to EGFR antibody concentration.
FIG. 12 shows that while none of the individual EGFR antibodies and none of th
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0557] Combinations of EGFR antibody LC1006-003 with 2F8-IgG1, 2F8-IgG4 or 2F8-F(ab)2 were tested in their ability to bind C1q and C4c, and to induce CDC. A431 cell line was used as target. It was found that relevant complement-deposition and -lysis was only observed in the presence of two human IgG1 Fc fragments (FIGS. 15 and 16).
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vildt!
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men det ser så faktisk ud som om de har afprøvet det med Zalu
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Jeg har spurgt genmab om de har testet HexaBody på Zalutumumab
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Det vil de ikke svare på
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og her det gamle abstract der er kombi af to antibodies http://www.biomedexperts.com/Abstract.bme/21832160/Epidermal_growth_factor_receptor_EGFR_antibody-induced_antibody-dependent_cellular_cytotoxicity_plays_a_prominent_role
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På GSK.com står Ofatumumab sc fase 2 i RA. http://www.gsk.com/investors/product-pipeline.html
Er det en fejl eller kører et sådant forsøg? Jeg kan ikke finde et på clinicaltrials.gov -
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