Genmab — Marts 2021
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Q: And then maybe on your PD-L1x4-1BB bispecific, Genmab mentioned one of the reasons they selected the 100 million [ph] dose, they wanted to have optimal trimer formation. And that kind of translates to about 60% to 70% occupancy for the PD-L1. How important is that formation of a trimer and why not target a higher PD-L1 occupancy from an efficacy perspective? Thank you.
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A: Ugur Sahin
Yeah, the trimer formation is - indeed the trimer formation is important for the conditional activation of the 4-1BB and with 100 microgram we have the sweet spot of PD-L1 or PD-1 blockade, plus trimer formation in a sufficiently long time. So we exploit here the optimal activation or functions of both arms of the antibody. And this is also in line with objective responses that we have observed with this component which are - which seem to be associated with this dose window.
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Thx EL
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"US: Amerikanske biotech aktier viser fortsat svaghed, trækker Genmab med ned" https://www.proinvestor.com/investornyt/673677/us-amerikanske-biotech-aktier-viser-fortsat-svaghed-traekker-genmab-med-ned
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Aktier/middag: Vestas og Ambu trækker C25 mod påskeferie i grønt
https://www.proinvestor.com/investornyt/673683/aktier-middag-vestas-og-ambu-traekker-c25-mod-paskeferie-i-gront -
Der er kommet en smule ild i raketten..på trods af US åbning:-)
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US noteringen er fint med. +3,75%
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Jeps
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Luk 2.088 (+3,37%).
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Det går fremad..:-)
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"Opad" er bedre.
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God påske til alle:-)
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Pyt Helge..bare den stiger...
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Q1 har sidste dag. Måske der bliver rokeret rundt i porteføljerne rundt omkring. Det vil være godt, hvis biotek blev moderne igen.
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Jeps..det er nok det som skal drive kursen det næste stykke tid.
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Onsdagens aktier: Ambu og grønne aktier til tops i påskefest på børsen:
https://www.proinvestor.com/investornyt/673703/onsdagens-aktier-ambu-og-gronne-aktier-til-tops-i-paskefest-pa-borsen -
For første gang siden 2008 er stort set alle Proinvestors annoncepladser udsolgt. Det er de nu og resten af foråret.
I påsken arbejder vi videre på at gøre dele af websitet responsivt med større mobilvenlighed.
Tak for et utal af indlæg i debat og chat. Tak for donationer. God påske til alle. BH Helge
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