<![CDATA[Og lidt mere om RA:]]>Og lidt mere om RA:
The results from the 24-week, placebo-controlled, double-blind phase of this trial confirm the previously reported efficacy of one course of intravenous ofatumumab in active RA.11 In addition, this study provides further information on the efficacy of ofatumumab in a well-defined RA patient population with long-standing disease not controlled by standard methotrexate therapy and not previously treated with other available biological DMARD therapies. Ofatumumab, at a dose of 700 mg administered twice, added to a background stable dose of methotrexate therapy, demonstrated a significantly greater ACR20 response at week 24 (primary endpoint) compared with placebo. Significantly greater improvements were observed in key secondary endpoints such as ACR50, ACR70, change from baseline in both DAS28–CRP and DAS28–ESR, EULAR response, physical function (HAQ–DI) and fatigue (FACIT–F).

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In summary, ofatumumab is a fully human mAb binding an epitope of CD20 distinct to that recognised by rituximab. A single course of two infusions of 700 mg was efficacious and safe in biological-naive, active RA patients on background methotrexate up to 24 weeks after treatment. As expected for a fully human mAb, ofatumumab did not induce immunogenicity.

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