SUMMARY OF THE INVENTION
The present invention relates to a shear and temperature stable aqueous antibody formulation.

In another embodiment, the invention relates to an anti-CD20 antibody formulation comprising an anti-CD20 antibody in the concentration range of 20-300 mg/mL, wherein the formulation further comprises 50 mM sodium acetate, 51 mM sodium chloride, 1% arginine free base, 0.05 mM EDTA, 0.02% polysorbate 80, and adjusted to pH 5.5. In another embodiment, the antibody is an anti-CD20 antibody fragment, such as a monoclonal antibody fragment. The preferred anti-CD20 antibody is ofatumumab.

In one embodiment, the invention relates to an ofatumumab formulation comprising a therapeutically effective amount of ofatumumab, wherein the formulation further comprises 10 to 100 mM sodium acetate, 25 to 100 mM sodium chloride, 0.5 to 5% arginine free base, 0.02 to 0.2 mM EDTA, 0.01 to 0.2% polysorbate 80 and adjusted to pH 5.0 to 7.0.

In one embodiment, the invention relates to an ofatumumab formulation comprising an ofatumumab in the concentration range of 20-300 mg/mL, wherein the formulation further comprises 50 mM sodium acetate, 51 mM sodium chloride, 1% arginine free base, 0.05 mM EDTA, 0.02% polysorbate 80, and adjusted to pH 5.5.

]]>https://dev.proinvestor.com/forum/topic/448326/jeg-faldt-over-dette-uden-at-jeg-lige-helt-forstr-det-s-har-gsk-vist-fet-patent-p-en-metode-til-at-stabilisere-ofatumumab-og-andre-antibodiesRSS for NodeSun, 21 Jun 2026 00:56:48 GMTThu, 03 Feb 2011 21:10:01 GMT60