<?xml version="1.0" encoding="UTF-8"?><rss xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:content="http://purl.org/rss/1.0/modules/content/" xmlns:atom="http://www.w3.org/2005/Atom" version="2.0"><channel><title><![CDATA[Tisotumab verdotin]]></title><description><![CDATA[<p dir="auto">Måske vi skulle forsøge at samle lidt viden om Humax-TF ADC´s chancer i cervical cancer - vi kender ikke meget til data endnu, men når man lige ser hvad jeg hurtigt kunne støve op en sen nattetime, så ligger tisotumab vedotin nogenlunde på niveau med andre behandlinger på respons.</p>
<p dir="auto">Her er først lige hvad der er godkendt til behandlingen i dag:</p>
<p dir="auto"><div class="card col-md-9 col-lg-6 position-relative link-preview p-0">



<a href="https://www.cancer.gov/about-cancer/treatment/drugs/cervical" title="Drugs Approved for Cervical Cancer">
<img src="https://www.cancer.gov/sites/www/files/ncids_header/logos/Logo_NCI_Mobile.svg" class="card-img-top not-responsive" style="max-height: 15rem;" alt="Link Preview Image" onerror="this.parentElement.remove()" />
</a>



<div class="card-body">
<h5 class="card-title">
<a class="text-decoration-none" href="https://www.cancer.gov/about-cancer/treatment/drugs/cervical">
Drugs Approved for Cervical Cancer
</a>
</h5>
<p class="card-text line-clamp-3">This page lists cancer drugs approved by the Food and Drug Administration (FDA) for cervical cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.</p>
</div>
<a href="https://www.cancer.gov/about-cancer/treatment/drugs/cervical" class="card-footer text-body-secondary small d-flex gap-2 align-items-center lh-2">



<img src="https://www.cancer.gov/profiles/custom/cgov_site/themes/custom/cgov/static/images/design-elements/icons/favicons/favicon.ico" alt="favicon" class="not-responsive overflow-hiddden" style="max-width: 21px; max-height: 21px;" onerror="this.remove()"/>







<p class="d-inline-block text-truncate mb-0"> <span class="text-secondary">(www.cancer.gov)</span></p>
</a>
</div></p>
<p dir="auto">Nu har jeg hurtigt kigget igennem nogle få abstracts der blev præsenteret indenfor cervical cancer på ASCO 2017 - her er lige et par enkelte uddrag af antistoffer, da det vel er det vi kan sammenligne med i første omgang:</p>
<p dir="auto">Pembrolizumab for previously treated advanced cervical squamous cell cancer: Preliminary results from the phase 2 KEYNOTE-158 study:Results: Among the first 47 patients with advanced cervical cancer who enrolled, ORR was 17% (95% CI, 8%-31%), with 3 confirmed and 5 unconfirmed responses. 41 (87%) patients had PD-L1-positive tumors, and ORR was independent of PD-L1 status. Among the 15 patients who had ≥27 weeks of follow-up, ORR was 27% (95% CI 8%-55%), with 3 confirmed responses and 1 unconfirmed response. Safety and updated efficacy data for 83 patients with ≥27 weeks of follow-up will be available for presentation.</p>
<p dir="auto"><a href="http://abstracts.asco.org/199/AbstView_199_194350.html" rel="nofollow ugc">http://abstracts.asco.org/199/AbstView_199_194350.html</a></p>
<p dir="auto">An open-label, multicohort, phase I/II study of nivolumab in patients with virus-associated tumors (CheckMate 358): Efficacy and safety in recurrent or metastatic (R/M) cervical, vaginal, and vulvar cancers: Results: Of 24 treated patients (pts), 19 had cervical and 5 had vaginal or vulvar cancer; median age was 51 y. At a median follow-up of 31 wks (range: 6-38), ORR was 20.8% (Table), and disease control rate (ORR + SD) was 70.8%. All responses were in pts with cervical cancer (ORR, 26.3%) and were observed regardless of PD-L1 or HPV status or number of prior R/M therapies. Median PFS was 5.5 mo (95% CI: 3.5, NR); median OS was NR</p>
<p dir="auto"><a href="http://abstracts.asco.org/199/AbstView_199_184153.html" rel="nofollow ugc">http://abstracts.asco.org/199/AbstView_199_184153.html</a></p>
<p dir="auto">Her også lige godkendelsen af bevazizumab (Avastin):</p>
<p dir="auto"><div class="card col-md-9 col-lg-6 position-relative link-preview p-0">

<div class="card-body">
<h5 class="card-title">
<a class="text-decoration-none" href="https://www.ucirvinehealth.org/news/2014/08/cervical-cancer-therapy-approved">

</a>
</h5>
<p class="card-text line-clamp-3"></p>
</div>
<a href="https://www.ucirvinehealth.org/news/2014/08/cervical-cancer-therapy-approved" class="card-footer text-body-secondary small d-flex gap-2 align-items-center lh-2">



<img src="https://www.ucirvinehealth.org/favicon.ico" alt="favicon" class="not-responsive overflow-hiddden" style="max-width: 21px; max-height: 21px;" onerror="this.remove()"/>



<p class="d-inline-block text-truncate mb-0"> <span class="text-secondary">(www.ucirvinehealth.org)</span></p>
</a>
</div></p>
<p dir="auto">Det var blot en start - kom gerne med det i finder !</p>
<p dir="auto">Mvh<br />
Sukkeralf</p>
]]></description><link>https://dev.proinvestor.com/forum/topic/439690/tisotumab-verdotin</link><generator>RSS for Node</generator><lastBuildDate>Fri, 17 Jul 2026 15:23:36 GMT</lastBuildDate><atom:link href="https://dev.proinvestor.com/forum/topic/439690.rss" rel="self" type="application/rss+xml"/><pubDate>Sat, 17 Jun 2017 22:29:07 GMT</pubDate><ttl>60</ttl><item><title><![CDATA[Reply to Tisotumab verdotin on Mon, 19 Jun 2017 10:22:23 GMT]]></title><description><![CDATA[<p dir="auto">Responsraterne kommer meget an på sygdommen, hvor syge patienterne er og om det er monoterapi eller kombinationsbehandling.</p>
<p dir="auto">Hvad der forventes i livmoderhalskræft ved jeg ikke eksakt, men eksempelvis nævnte Jan på et tidspunkt at daratumumab som minimum helst skulle opnå 20% som monoterapi i "4 linie" MM.</p>
<p dir="auto">Så 17% er formentlig i underkanten, mens tisotumabs responsrate på lige over 30% godt kunne være nok - men responsraten er jo kun en lille del af billedet, så også derfor det pt er svært at vurdere om der er en fremtid for tisotumab.</p>
<p dir="auto">Jeg synes det er fair at det umiddelbart ikke giver den vilde kursreaktion indtil vi får mere viden.</p>
<p dir="auto">Mvh<br />
Sukkeralf</p>
]]></description><link>https://dev.proinvestor.com/forum/post/9452480</link><guid isPermaLink="true">https://dev.proinvestor.com/forum/post/9452480</guid><dc:creator><![CDATA[Sukkeralf]]></dc:creator><pubDate>Mon, 19 Jun 2017 10:22:23 GMT</pubDate></item><item><title><![CDATA[Reply to Tisotumab verdotin on Mon, 19 Jun 2017 10:04:47 GMT]]></title><description><![CDATA[<p dir="auto">Hej Sukkeralf<br />
Super god ide med oversigten her. Lige et temmelig banalt spørgsmål dog. Er en responsrate på 17% godt? For en uindviet som jeg lyder det som et enormt lavt tal. Er det normalt at det ikke er højere?</p>
]]></description><link>https://dev.proinvestor.com/forum/post/9452498</link><guid isPermaLink="true">https://dev.proinvestor.com/forum/post/9452498</guid><dc:creator><![CDATA[Kænned]]></dc:creator><pubDate>Mon, 19 Jun 2017 10:04:47 GMT</pubDate></item><item><title><![CDATA[Reply to Tisotumab verdotin on Sun, 18 Jun 2017 19:56:33 GMT]]></title><description><![CDATA[<p dir="auto">Lidt monoterapidata for bevacizumab på side 13..</p>
<p dir="auto"><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037327/#!po=41.6667" rel="nofollow ugc">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037327/#!po=41.6667</a></p>
]]></description><link>https://dev.proinvestor.com/forum/post/9452481</link><guid isPermaLink="true">https://dev.proinvestor.com/forum/post/9452481</guid><dc:creator><![CDATA[Sukkeralf]]></dc:creator><pubDate>Sun, 18 Jun 2017 19:56:33 GMT</pubDate></item></channel></rss>