Genmab — December 2022

gentogen

Nu vi er ved det, så er efterbehandlngen af Lu AF82422 in Participants With Multiple System Atrophy (AMULET) netop blevet forlænget. Ikke at man kan lægge ret meget i det, men måske alligevel et lille positivt tegn???

GeorgeBest

Exciting responses to bispecific epcoritamab for Richter's transformed CLL, which can be very tricky to treat https://twitter.com/eddie_cliff/status/1601717217082900480?s=61&t=XzZjo9n9cJC0DuYLqTWXUw

Helge_LarsenPI-redaktør

Godmorgen.

ProinvestorNEWS

'New lease on life' for blood cancer patients as experimental therapy treats 73 PERCENT of patients in global clinical trials

The treatment targets recurring multiple myeloma, a type of blood cancer
More than 30 percent of trial patients saw all traces of their cancer disappear
Talquetamab work as well or better than similar multiple myeloma treatments https://www.dailymail.co.uk/health/article-11522823/New-blood-cancer-therapy-treats-seven-10-patients.html

ProinvestorNEWS

Raj Chakraborty
@rajshekharucms
·
11 t
Although I am super excited about teclistamab combinations in earlier lines of therapy, 6.25% fatal AEs 2/2 infection in Dara-Tec-Len is concerning. Need to develop new strategies to mitigate infection risk such that greater efficacy is not neutralized by high tox https://twitter.com/rajshekharucms/status/1601652144410886150

ProinvestorNEWS

oseph Mikhael
@jmikhaelmd
master presenter Ajai Chari presenting Talquetamab a bispecific antibody targeting GPRC5D. Amazing 74% ORR and even more remarkable low infection rates grade 3/4 at 17% and 12%. This is remarkable and may likely be the next bispecific and First GPRC5D available https://twitter.com/jmikhaelmd/status/1601640239877222403

ProinvestorNEWS

Ben Derman
@bdermanmd
·
11 t
Rub some ‘DRT’ on it. MajesTEC-2 with Dara/Len/Tec. ORR 93.5% in a less refractory population with high rates of CR (55%). No data on mrd negativity among the CR population. But definitely makes a case for combination strategies for teclistamabhttps://twitter.com/bdermanmd/status/1601652148151779328

ProinvestorNEWS

MyelomaTeacher - Cindy Chmielewski
@MyelomaTeacher
Hope - for RRMM
https://twitter.com/MyelomaTeacher/status/1601641808064581633

Stroka

God morgen

Stroka

Det ser godt ud for talquetamab og teclistamab.

ProinvestorNEWS

Jim Omel
@IMFjimMYELOMA
More Than 70% of Heavily Pretreated Patients Taking Talquetamab for Multiple Myeloma See Responses That “Deepen Over Time” https://ajmc.com/view/70-of-heavily-pretreated-patients-taking-talquetamab-for-multiple-myeloma-see-responses-that-deepen-over-time-
via @AJMC_Journal
More exciting immunotherapy news from ASH. 70% response to a new myeloma cell surface target. https://twitter.com/IMFjimMYELOMA/status/1601748849156321280

E_L

Janssen Presents First Data from MajesTEC-2 Trial of TECVAYLI (teclistamab-cqyv) in Combination with DARZALEX FASPRO (daratumumab and hyaluronidase-fihj) and Lenalidomide in Relapsed or Refractory Multiple Myeloma https://www.janssen.com/janssen-presents-first-data-majestec-2-trial-tecvayli-teclistamab-cqyv-combination-darzalex-faspro

E_L

Janssen Presents New Data for Talquetamab, a First-in-Class GPRC5DxCD3 Bispecific Antibody, Suggesting Durable Responses in Patients with Heavily Pretreated Multiple Myeloma https://www.janssen.com/janssen-presents-new-data-talquetamab-first-class-gprc5dxcd3-bispecific-antibody-suggesting-durable

E_L

It's a while ago this was written 'Assuming epco gets approved, and 1 biontech duobody, then for these first 9 Genmab approved antibodies, 8 of them will be blockbusters, Kesimpta will be multiple blockbuster, Teclistamab, Talquetamab, Tepezza now are prognosed for >$4bn and Dara and Rybrevant >$5bn. That is just unheard of for a biotech.' but seems fully on track... maybe Mim8 will be #9 though, as GB suggested or even Inclacumab...