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  3. Genmab
  4. Genmab — Januar 2026

Genmab — Januar 2026

Planlagt Fastgjort Låst Flyttet Genmab
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  • E Offline
    E Offline
    E_L
    wrote on sidst redigeret af
    #125

    https://ir.genmab.com/news-releases/news-release-details/genmab-announces-topline-results-epcoritamab-duobodyr-cd3xcd20 Genmab Announces Topline Results for Epcoritamab (DuoBody® CD3xCD20) from Phase 3 EPCORE® DLBCL-1 Trial in Patients with Relapsed/Refractory Diffuse Large B-cell Lymphoma (DLBCL)

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    • S Offline
      S Offline
      Sukkeralf
      wrote on sidst redigeret af
      #126

      Ikke godt: The study did not demonstrate a statistically significant improvement in overall survival (OS) (HR: 0.96 [95% CI 0.77 to 1.20])

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      • SolsenS Offline
        SolsenS Offline
        Solsen
        wrote on sidst redigeret af
        #127

        Det var ærgerligt. Monoterapi er ikke godt nok. Resultatet vil give lidt usikkerhed.

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        • E Offline
          E Offline
          E_L
          wrote on sidst redigeret af
          #128

          OS indeed disappoints -on the first look. we all know though during what period this trial was conducted, and analysis will have to show how disappointing it really is, or if Covid circumstances led to this result, and other therapies after controll arm relapse which could be a factor...

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #129

            PFS was a win

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            • E Offline
              E Offline
              E_L
              wrote on sidst redigeret af
              #130

              the drop seems excessive, but i can understand it, as we don't know the exact additional circumstances

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              • E Offline
                E Offline
                E_L
                wrote on sidst redigeret af
                #131

                reality is also that mono therapy will not really matter that much going forward , me thinks...

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                • E Offline
                  E Offline
                  E_L
                  wrote on sidst redigeret af
                  #132

                  ABBV hardly blinked, but it is offcourse still a small impact on Abbvie

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                  • E Offline
                    E Offline
                    E_L
                    wrote on sidst redigeret af
                    #133

                    it is a shame this news did not come just before JPM, Jan could have explained possibel causes a bit... we may not hear any comments on it now until Q1 in Feb?

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                    • SolsenS Offline
                      SolsenS Offline
                      Solsen
                      wrote on sidst redigeret af
                      #134

                      https://borsen.dk/nyheder/virksomheder/genmab-viser-igen-lovende-kraeftdata-i-nyt-studie?b_source=borsen&b_medium=row_-1&b_campaign=latest_news_1 🙂 ???

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                      • P Offline
                        P Offline
                        perstu
                        wrote on sidst redigeret af
                        #135

                        Både Børsen og Finans har lovende overskrifter - "Genmab viser igen lovende kræftdata..

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                        • E Offline
                          E Offline
                          E_L
                          wrote on sidst redigeret af
                          #136

                          Truist maintains optimism for 2026 read-out after Genmab’s Phase 3 trial OS miss https://www.tipranks.com/news/the-fly/truist-maintains-optimism-for-2026-read-out-after-genmabs-phase-3-trial-os-miss-thefly#google_vignette

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                          • E Offline
                            E Offline
                            E_L
                            wrote on sidst redigeret af
                            #137

                            Truist notes Genmab (GMAB) reported Phase 3 results from the EPCORE DLBCL-1 trial in transplant-ineligible second-line positive diffuse large B-cell lymphoma patients. The study missed its overall survival endpoint. However, this outcome does not change the firm’s view on the key frontline DLBCL study, and Truist remains optimistic for a positive read-out this year. The firm has a Buy rating on the shares with a price target of $48.

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                            • J Offline
                              J Offline
                              JKY_VH
                              wrote on sidst redigeret af
                              #138

                              Fra Børsen "Og studiet peger ifølge Genmab på en forbedring af den progressionsfri overlevelse, når Epcoritamab blev anvendt som monoterapi.

                              “Derudover blev der observeret forbedringer i den komplette responsrate, responsvarigheden og tiden til næste behandling blandt patienter, der blev behandlet med Epcoritamab som monoterapi,” skriver Genmab i en meddelelse.

                              Det er ifølge Genmab det første fase 3-studie til dato, der har vist en forbedret progressionsfri overlevelse i patienter med

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                              • J Offline
                                J Offline
                                JKY_VH
                                wrote on sidst redigeret af
                                #139

                                Til gengæld har Epcore DLBCL-1-studiet ikke kunnet vise en statistisk signifikant forbedring af den overordnede overlevelsesgrad.

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                                • SolsenS Offline
                                  SolsenS Offline
                                  Solsen
                                  wrote on sidst redigeret af
                                  #140

                                  Og det er netop det ultimative endpoint. Så ikke nogen succes.

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                                  • E Offline
                                    E Offline
                                    E_L
                                    wrote on sidst redigeret af
                                    #141

                                    which is why they will need to discuss with FDA. AbbVie is an experienced partner, that may pay off now. we'll see...

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                                    • E Offline
                                      E Offline
                                      E_L
                                      wrote on sidst redigeret af
                                      #142

                                      After AbbVie and Genmab's ph. 3 survival miss for Epkinly in DLBCL, what's next? https://www.fiercepharma.com/pharma/after-abbvie-and-genmabs-ph-3-survival-miss-epkinly-dlbcl-whats-next

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                                      • P Offline
                                        P Offline
                                        Pensionisten
                                        wrote on sidst redigeret af
                                        #143

                                        Kommer hjem lidt sent fredag aften, og ser et hav af meddelser omkring Genmab. Må indrømme at jeg bliver lidt rundtosset. Nogle medier m.v. udlægger det som en fiasko, her på chatten lidt både/og. Og Børsen nævner en succes. Jeg er ikke fagkyndig, men plejer sånogenlunde at forstå. Men lige nu ligner jeg mere et ????????. Håber, der er nogle af jer, der kan bringe lidt lys over dette´, i løbet af weekenden. 🙂

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                                        • StockBullS Offline
                                          StockBullS Offline
                                          StockBull
                                          wrote on sidst redigeret af
                                          #144

                                          Lukkede desværre i 2077 i US - mon ikke kurs 2000 skal testes i næste uge.

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