Genmab — Juni 2024
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Nok snarere at pd-l1 blokaden forstærker 4-1bb-stimuleringen, som aktiverer t-cellerne og nok-cellerne: Acasunlimab is designed to elicit an antitumor response via conditional activation of 4-1BB on T cells and natural killer cells, which is strictly dependent on simultaneous binding of the PD-L1 arm.
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For dem, der gerne vil se, hvordan overliggeren befinder sig i nsclc first line - https://ascopubs.org/doi/10.1200/JCO.21.01497
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…men derfor kan Acasunlimab jo stadig komme i first line. Sjovt som ORR stiger - men OS i first line er ikke markant anderledes end OS i second line…
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Det bliver super interessant at følge OS data efter din trøffel-gris action ifht protokollen
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Lahn , i think the original link does not work anymore, it is in this list, p609 i believe, maybe you can search from there https://sitc.sitcancer.org/2019/abstracts/titles/index.php?filter=4-1bb
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Thx, found it on pubmed by title https://pubmed.ncbi.nlm .nih.gov/37259060/
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An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicity - PubMed
We generated an Fc-muted anti-PD-L1x4-1BB BsAb, HK010, with a distinguished structural interaction with PD-L1 and 4-1BB that exhibits a synergistic antitumor effect by blocking the PD-1/PD-L1 signaling pathway and stimulating the 4-1BB signaling pathway simultaneously. It is strictly dependent on th …
PubMed (pubmed.ncbi.nlm.nih.gov)
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Perhaps news from FDA on Epco RR FL later tonight?
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