Genmab — Juni 2023

[E_L]

results from 2 cohorts in EPCORE NH2 investigating epcoritamab+rituximab & lenalidomide in patients with R/R FL. This combination showed potent anti-tumor activity and a manageable safety profile in patients with high-risk disease #lymsm https://twitter.com/lymphomahub/status/1667162491560837120

[E_L]

@NBahlis
presents results of the TRIMM-2 trial (talquetamab + daratumumab), targeting GPRC5D & CD38, ORR of 84% w/ response rate within 1st round of therapy.
**Impressively, 78.6% pts were refractory & heavily pre-exposed to a CD38 https://twitter.com/MyelomaCanada/status/1667475172201201664 https://twitter.com/MM_Hub/status/1667475083022024707

[E_L]

Follicular #lymphoma (#FL) accounts for ~20% of all non-Hodgkin’s lymphoma (NHL) cases globally and is the most common subtype of indolent, or slow growing, NHL. https://twitter.com/Genmab/status/1667275399364001793

[Bulder]

Carvykti: https://haematologisktidsskrift.dk/sygdomme/myeloma/1190-finale-cartitude-1-data-storste-pfs-gevinst-for-tungt-forbehandlede-rrmm-patienter-til-dato.html. https://haematologisktidsskrift.dk/sygdomme/myeloma/1194-forste-data-fra-cartitude-4-meget-flotte-responser-hos-lenalidomid-refraktaere-myelomatose-patienter.html

[Klarussen]

Dejligt at se

[E_L]

EPCORE FL-1 closes further enrollment to one of the groups ; i assume this means the correct dose is found and they no longer need to continue that cohort. Saves recruitement of 122 patients as Enrollment goes from 642 to 520 https://www.clinicaltrials.gov/ct2/history/NCT05409066?A=47&B=48&C=merged#StudyPageTop

[E_L]

New trial - Daratumumab Maintenance Therapy for Improving Survival in Patients With Light Chain Amyloidosis, EMILIA Trial https://www.clinicaltrials.gov/ct2/show/NCT05898646

[Bulder]

Looks like they already now know that dose A is better than dose B. They just need to find out HOW much better. Or could it be the other way round?

[E_L]

that is also what i thought
Bulder

[Helge_LarsenPI-redaktør]

Godmorgen

[Stroka]

God morgen

[Pensionisten]

Så er det vel i aften, der er Fireside hos GS https://event.webcasts.com/starthere.jsp?ei=1618997&tp_key=ab369db32b&tp_special=8

[Bulder]

Opdaterede EPCORE NHL-2-data støtter op om epcoritamab + R-CHOP i 1L til højrisiko DLBCL https://haematologisktidsskrift.dk/sygdomme/lymfoma/1201-opdaterede-epcore-nhl-2-data-stotter-op-om-epcoritamab-r-chop-i-1l-til-hojrisiko-dlbcl.html

[JKY_VH]

tak Bulder

[Bulder]

Men der er lang tid til vi ser data fra fase 3-studiet. Først startet i år.

[E_L]

Genmab, l'autre success-story danoise de la santé https://www.zonebourse.com/cours/action/GENMAB-A-S-63733191/actualite/Genmab-l-autre-success-story-danoise-de-la-sante-44098213/?utm_medium=RSS&utm_source=googlenews&utm_content=20230613

[Mogan]

Hvor mon vi har bunden denne gang? Så der kan købes ind

[JKY_VH]

Det plejer SB at have et kvalificeret bud på.

[Riis7]

Flot sidste plads i c25 i år
efter snart 6 mån, men var os vinder sidste år sammen med Novo:-) Novo har så klaret sig noget bedre i år:-)

[JKY_VH]

Ja, alt godt sagt om Genmab, men der er jo en grund til at Novo indtil videre har klaret sig bedre i år en Genmab. De har opjusteret salgsvæksten til omkring 30%, slankepræparatet Wegovy har alene i USA en målgruppe på over 100 mio. voksne personer (mod 70.000 tilfælde af knoglemarvskræft), man har fordoblet produktionskapaciteten vha. en kontraktproducent. Derudover deler Novo ud af overskuddet til aktionærerne, hvorimod Genmab deler warrents ud til medarbejdere, ledelsen og bestyrelsen.