Genmab — December 2022

[ProinvestorNEWS]

MyelomaTeacher - Cindy Chmielewski
@MyelomaTeacher
Hope - for RRMM
https://twitter.com/MyelomaTeacher/status/1601641808064581633

[Stroka]

God morgen

[Stroka]

Det ser godt ud for talquetamab og teclistamab.

[ProinvestorNEWS]

Jim Omel
@IMFjimMYELOMA
More Than 70% of Heavily Pretreated Patients Taking Talquetamab for Multiple Myeloma See Responses That “Deepen Over Time” https://ajmc.com/view/70-of-heavily-pretreated-patients-taking-talquetamab-for-multiple-myeloma-see-responses-that-deepen-over-time-
via @AJMC_Journal
More exciting immunotherapy news from ASH. 70% response to a new myeloma cell surface target. https://twitter.com/IMFjimMYELOMA/status/1601748849156321280

[E_L]

Janssen Presents First Data from MajesTEC-2 Trial of TECVAYLI (teclistamab-cqyv) in Combination with DARZALEX FASPRO (daratumumab and hyaluronidase-fihj) and Lenalidomide in Relapsed or Refractory Multiple Myeloma https://www.janssen.com/janssen-presents-first-data-majestec-2-trial-tecvayli-teclistamab-cqyv-combination-darzalex-faspro

[E_L]

Janssen Presents New Data for Talquetamab, a First-in-Class GPRC5DxCD3 Bispecific Antibody, Suggesting Durable Responses in Patients with Heavily Pretreated Multiple Myeloma https://www.janssen.com/janssen-presents-new-data-talquetamab-first-class-gprc5dxcd3-bispecific-antibody-suggesting-durable

[E_L]

It's a while ago this was written 'Assuming epco gets approved, and 1 biontech duobody, then for these first 9 Genmab approved antibodies, 8 of them will be blockbusters, Kesimpta will be multiple blockbuster, Teclistamab, Talquetamab, Tepezza now are prognosed for >$4bn and Dara and Rybrevant >$5bn. That is just unheard of for a biotech.' but seems fully on track... maybe Mim8 will be #9 though, as GB suggested or even Inclacumab...

[E_L]

Ash 2022 – talquetamab heads to the regulators https://www.evaluate.com/vantage/articles/events/conferences-trial-results/ash-2022-talquetamab-heads-regulators

[E_L]

PET scan for Richters / epco https://twitter.com/asernapareja/status/1601716206050115584/photo/1

[Bulder]

Seems like a little concern over the fatal infections in the tec-dara-len combo. One covid and one sepsis. Hope this will be discussed on R&D Day.

[Bulder]

https://www.youtube.com/watch?v=8yirKYro2cw talquetamab

[ProinvestorNEWS]

Just a moment...

(www.proinvestor.com)

[GeorgeBest]

@Bulder. Jan will probably say it is a Janssen product, and refer the analyst to them.

[Bulder]

Also talq had 2 deaths due to covid. Maybe this problem will be solved when covid is over.

[Bulder]

GB: I think they should discuss the general issue with risk of infections and bispecifics.

[E_L]

at the same time, according to Dr Chari: “If you measure Covid antibodies, patients on [talquetamab] are producing antibodies. That’s a really different signal than what we’ve seen before.”

[Bulder]

Ye s, but as he says, it is tragic to loose a cr- patient to covid. I would like to hear if they can come up with something to avoid infections.

[Bulder]

Does anybody know when hex38 will be presented.

[E_L]

tonight https://ash.confex.com/ash/2022/webprogram/Paper159116.html

[E_L]

but it is a poster, so you have to hope someone will post something on twitter, we'll probably have to wait for the R&D