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  4. Genmab — Februar 2022

Genmab — Februar 2022

Planlagt Fastgjort Låst Flyttet Genmab
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  • E Offline
    E Offline
    E_L
    wrote on sidst redigeret af
    #71

    AbbVie (ABBV) Q4 2021 Earnings Call Transcript https://www.fool.com/earnings/call-transcripts/2022/02/03/abbvie-abbv-q4-2021-earnings-call-transcript/

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    • E Offline
      E Offline
      E_L
      wrote on sidst redigeret af
      #72

      We are also making very good progress with epcoritamab, where we continue to generate strong data in early stage studies to support our view that epcoritamab has the potential to become a differentiated and best-in-class CD3xCD20 bispecific across several B-cell malignancies, including diffuse B cell and follicular lymphomas. We'll see monotherapy data in the third quarter from the Phase 2 expansion cohort in DLBCL, which has the potential to support a submission for accelerated approval in the

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      • E Offline
        E Offline
        E_L
        wrote on sidst redigeret af
        #73

        in the second half of this year. We also have a Phase 3 study ongoing in third-line relapsed/refractory DLBCL, and we plan to initiate several additional Phase 3 trials this year, including studies in earlier lines of therapy for diffuse B-cell lymphoma in multiple combinations, as well as in follicular lymphoma in combination with rituximab and Revlimid.

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        • E Offline
          E Offline
          E_L
          wrote on sidst redigeret af
          #74

          Q: So first, on epco, could you just comment around your confidence around accelerated approval here in DLBCL and how you're thinking about that opportunity in the near term?

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #75

            A: So on epco -- we have a high degree of confidence in epco overall. It continues to deliver very strong results, high overall response rates, very deep responses, good complete response rates across a number of indications, DLBCL and follicular lymphoma both. With respect to the confidence in accelerated approval for diffuse large B-cell lymphoma, when we look at the data, we think it clearly exceeds the benchmarks of available therapies in highly pretreated refractory patients.

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            • E Offline
              E Offline
              E_L
              wrote on sidst redigeret af
              #76

              So we would think that accelerated approval should be supported by those data.

              We'll allow the data to continue to mature from the expansion cohorts and have our final regulatory discussions later on this year to set up that accelerated approval submission. So it certainly is in our planning, and we think it's very supportable based on the data.

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              • S Offline
                S Offline
                Sukkeralf
                wrote on sidst redigeret af
                #77

                Nice - epco is so important

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                • BulderB Offline
                  BulderB Offline
                  Bulder
                  wrote on sidst redigeret af
                  #78

                  Very nice - only would I have expected data from the expansion cohort earlier than Q3.

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                  • P Offline
                    P Offline
                    ProinvestorNEWS
                    wrote on sidst redigeret af
                    #79

                    Aktier/åbning: Tunge omkostninger trækker Danske Bank til bunds
                    https://www.proinvestor.com/investornyt/775626/aktier-abning-tunge-omkostninger-traekker-danske-bank-til-bunds

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                    • E Offline
                      E Offline
                      E_L
                      wrote on sidst redigeret af
                      #80

                      yes, me too. but I think we could already sense from Jan last quarter that it wasn't going as fast as he was hoping for. Hospital care was a mess again in many countries last quarter; let's hope that will slowly improve from now...

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                      • L Offline
                        L Offline
                        lahn1
                        wrote on sidst redigeret af
                        #81

                        Super positivt med "and we plan to initiate several additional Phase 3 trials this year" men hvordan kommer det til at se ud på 2022 guidance. Bliver det endnu en guidance hvor market skuffes over bundlinien ?

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                        • BulderB Offline
                          BulderB Offline
                          Bulder
                          wrote on sidst redigeret af
                          #82

                          Nok ingen tvivl om at omkostningerne øges i år. Til gengæld vil de måske være knap så konservative på dara-salget, som sidste år.

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                          • StockBullS Offline
                            StockBullS Offline
                            StockBull
                            wrote on sidst redigeret af
                            #83

                            Som helhed tror jeg ikke markedet er skuffet over de sidste 6-8 års kurs ride og PE på +80 for 3-4 måneder siden taler sit tydlige sprog, at markedet belønner genmab med stigende kurs. De fald vi ser nu er p.g.a NBI falder. Så hvis / når NBI vender vil jeg tror Genmab outperformer NBI

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                            • StockBullS Offline
                              StockBullS Offline
                              StockBull
                              wrote on sidst redigeret af
                              #84

                              Omkostninger og omsætning går hånd i hånd og mon ikke vi skal +30% i 2022 i.f.t 2021. Gætter på 12 mia kr i omsætning for 2022 - bundlinie 3.6-4

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                              • D Offline
                                D Offline
                                deleted-user
                                wrote on sidst redigeret af
                                #85

                                Genmab har nemmere ved at overraske, som i 2021, med højere omsætning og færre omkostninger. Det er vist nævnt tidligere i vores budget diskussioner. Vi når 5 mia. på EBITDA i 2022

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                                • S Offline
                                  S Offline
                                  Sukkeralf
                                  wrote on sidst redigeret af
                                  #86

                                  Angående udgifter til Epco så deles de jo med Abbvie - og desuden falder der milestones af til Genmab, så mon ikke det går

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                                  • M Offline
                                    M Offline
                                    Mcjean
                                    wrote on sidst redigeret af
                                    #87

                                    jo

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                                    • StockBullS Offline
                                      StockBullS Offline
                                      StockBull
                                      wrote on sidst redigeret af
                                      #88

                                      @LLi. Så vi jo på det samme efter 22% i skat af de 5 mia = 3.9 i profit

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                                      • StockBullS Offline
                                        StockBullS Offline
                                        StockBull
                                        wrote on sidst redigeret af
                                        #89

                                        Men om de kan slippe billigere end 22% i skat bliver jeg svar skyldig 🙂

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                                        • D Offline
                                          D Offline
                                          deleted-user
                                          wrote on sidst redigeret af
                                          #90

                                          hehe og jeg holder mig lidt tilbage for ikke, at fremstå som en klovn om 12 md. Jeg har intervallet 5-6 mia. og hælder mest mod 6 mia. Tror milestones rammer 1,5 mia. i 2022 og gør jo dit bud på 0,6 til skamme 🙂

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