Genmab — December 2021

[GeorgeBest]

Denne onkolog undrer sig over hvorfor man overhovedet vil anvende CAR-T i MM, når man snart kan få Teclistamab som vil være „safer, better, easier and cheaper“ https://twitter.com/drpaulydesantis/status/1466262720127258625?s=21

[Sukkeralf]

Detailed results from Roche's POLARIX study are poised to be one of the highlights at next week's annual meeting of the American Society of Hematology (ASH).

[Sukkeralf]

Roche notes that POLARIX is the first positive DLBCL Phase III study in a curative setting for two decades. Furthermore, it has suggested that sales of Polivy could peak at around $2 billion if the antibody-drug conjugate (ADC) becomes established as a new standard of care in the first-line setting.

[Sukkeralf]

In response to publication of the abstract, we snap-polled 43 oncologists, 56% of whom said the Polivy-based regimen looks superior to current standard of care based on PFS data alone.

[Sukkeralf]

35% says acceptable adverse effect profile and 51% says manageable

[Sukkeralf]

Taking efficacy and safety into account, results from POLARIX were described by 44% of oncologists as clinically meaningful and by a further 40% as promising, suggestive that physicians still want to see further detailed results and ideally a survival benefit (despite DLBLC being a relatively slowly progressing disease).

[Sukkeralf]

And then they want to see OS data

[Sukkeralf]

Regarding Genmabs DuoBody agreement with Janssen we maybe could get an idea of how backloaded the deal is by looking at Zymeworks deal with Janssen.

[Sukkeralf]

For 6 programs Zymeworks got 50 million dollars upfront and are eligible for up to $282M in development milestone payments as well as $1.12B in commercial milestones. Thats about 233 milliion dollars pr program which is bit more than Genmabs deal but also 5 years later. So kind of the same I guess.

[Sukkeralf]

So that means around 20% of the milestone are development and 80% commercial - so quite backloaded I must say

[Sukkeralf]

Zymeworks also get single mid digit royalty

[svak]

ser ikke ud til at godkendelsen hos FDA på dara kyprolis skal give noget - positivt ja - og fald som standard

[Sukkeralf]

NBI faldt en del i går aftes

[StockBull]

DAGKORT: Trendkanalen stadig intakt. RSI indikere oversolgt så krydret med lidt godt nyt bør kursen snart rykke opad. MACD kan ses mindre lyserøde stage fra dag til dag så det tyder på vi snart skal til at se de foretrukne grønne lys. https://nbg1.your-objectstorage.com/proinvestor-dev/forum/boards/99079_Skaermbillede_2021_12_02_150642_genmabbb.jpg

[Bulder]

@GB 5:48: Det er jo det vi har sagt hele tiden

[GeorgeBest]

Rigtigt Bulder, men også rart at eksperterne mener det samme

[deleted-user]

• andre eksperter

[Sukkeralf]

Under 2500 - thats sad

[Solsen]

Ja det er trist at se på. Godt for PAL skatten

[Solsen]

Støttepunkterne er vel lidt længere nede nu. Og 2300 ser ud til at kunne give en mere fast bund i min verden. Håber ikke vi skal derned trods alt.