Genmab — December 2021

[Bulder]

a flat royalty rate of 20% on sales of HexaBody-CD38 until a specified time in 2031, followed by 13-20% tiered royalties on sales thereafter.

[Bulder]

• milestones: Should this occur, Janssen will pay Genmab a USD 150 million option exercise fee and up to USD 125 million in development milestones,

[Bulder]

Det bliver næsten DKK 1 mia for at opte in.

[Bulder]

For de penge kan Genmab financiere to fase 3 studier med 500 pts i hver.

[E_L]

Trillium Therapeutics starting a combination trial with Dara with CD47 antibodies; we haven't heard much on Genmab / BliNK 's CD47 plans , have we? btw Trillium is now Pfizer

[gentogen]

Angående DR5/DR5 kom der jo i foråret denne artikel "Potent preclinical activity of HexaBody-DR5/DR5 in relapsed and/or refractory multiple myeloma", så måske muligheder???

[gentogen]

Supporting this, bortezomib combined with HexaBody-DR5/DR5 synergistically increased cytotoxicity in MM cells in 7 of 11 newly diagnosed patients.

[gentogen]

Just a moment...

(ashpublications.org)

[E_L]

no, i don't think so. it is dead. preclinical activity is the reason to start in human trials, but if results aren't what you hoped for you stop it as fast as you can

[Bulder]

They probably have more faith in hex38 regarding MM.

[E_L]

hex38 seems to be all about safety. genmab have enough cd38 knowledge to know if hex38 is potent enough to beat Dara i would think

[E_L]

every day that goes by without a 'Hold' on that trial is a + lol

[E_L]

i imagine they move this very very slowly to prevent that from happening... which is also why i am not so sure we should expect too much info at the R&D day

[E_L]

it is why i asked Jan how many patients had been dosed yet at Q&A, but he didn't answer

[E_L]

on the other hand, you could probably not have a better starting point for this drug then Vejle hospital with Plesner ; if anyone would know how to move this forward it is probably him

[Bulder]

They haven

[Bulder]

t updated on this study since Sept 2. So accoeding to that it is still only Vejle and Karolinska recruiting.

[E_L]

we saw with the epco R/R CLL trial only 7 patients were enrolled in about 7/8 months; i wouldn't be surprised if this is going with the same speed

[E_L]

'speed'
not being the best choice of words here

[E_L]

https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-darzalex-faspro-kyprolis-and-dexamethasone-multiple-myeloma